3 research outputs found

    Near-Field Pattern of Large Aperture Higher Order Mode Generator Using Backpropagated Fields in Free Space

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    This paper reports the estimation of the electric field from a large aperture cavity that generates a higher order mode by backpropagation of fields measured in free space. A higher order mode of a TE6,2 mode at 94 GHz is designed and fabricated using a quasi-optical manner for the analysis. The backpropagating field at the aperture is compared with the measured field. The field estimated at the aperture is used to analyze the mode information, such as the amount of mode mixture of two different rotating fields and the phase difference between two modes. This paper provides a quantitative way to analyze the rotating cylindrical modes generated from an oversized cavity.close2

    Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration

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    Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest. Previously, we have shown that activation of lysophosphatidic acid receptors (LPARs) via gintonin application potentiates synaptic transmission by the blockade of K+ channels in the mature hippocampus. However, whether gintonin may exert any beneficial impact directly on cognition at the neural circuitry level and the behavioral level has not been investigated. Methods: In the current study, we took advantage of gintonin, a novel LPAR agonist, to investigate the effect of gintonin-mediated LPAR activation on cognitive performances. Hippocampus-dependent fear memory test, synaptic plasticity in the hippocampal brain slices, and quantitative analysis on synaptic plasticity-related proteins were used. Results: Daily oral administration of gintonin for 1 wk significantly improved fear memory retention in the contextual fear-conditioning test in mice. We also found that oral administration of gintonin for 1 wk increased the expression of learning and memory-related proteins such as phosphorylated cyclic adenosine monophosphate-response element binding (CREB) protein and brain-derived neurotrophic factor (BDNF). In addition, prolonged gintonin administration enhanced long-term potentiation in the hippocampus. Conclusion: Our observations suggest that the systemic gintonin administration could successfully improve contextual memory formation at the molecular and synaptic levels as well as the behavioral level. Therefore, oral administration of gintonin may serve as an effective noninvasive, nonsurgical method of enhancing cognitive functions
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